Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html


Study Counts

Type Study_count
Total_Studies 272
interventional 231
Observational 40
Registry 1

Studies over Time by Start Date

```

Interventional Trials

Intervention Type

intervention_type Study_Count
Drug 111
Drug|placebo 77
Other 13
Device 8
Behavioral 7
Device|Drug 3
Behavioral|Other 2
Dietary Supplement 2
Drug|Other 2
Other|placebo 2
Behavioral|Diagnostic Test|Other 1
Dietary Supplement|placebo 1
Drug|Procedure 1
Procedure 1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Yearly studies for each intervention by start date

Studies by Country

Country Study_Count
United States 88
NA 21
Japan 11
China 9
France 9
Germany 9
Egypt 8
Korea, Republic of 6
Switzerland 5
United States|Canada 5
Brazil 4
Norway 4
Turkey 4
Iran, Islamic Republic of 3
Australia 2
Canada 2
Denmark 2
Israel 2
Taiwan 2
Thailand 2
Argentina 1
Australia|Czech Republic|Denmark|Germany|Italy|Norway|Portugal|Slovakia|Spain|Sweden|Switzerland 1
Austria|Belgium|Finland|Germany|Ireland|Netherlands|Slovakia|Spain|United Kingdom 1
Austria|Germany|Netherlands|Norway|Sweden 1
Austria|Germany|Spain 1
Austria|Germany|Sweden|Switzerland 1
Belgium 1
Denmark|Finland|Germany|Ireland|Italy|Norway|Spain|Sweden|United Kingdom 1
Finland 1
Finland|France|Germany|Ireland|Italy|Korea, Republic of|Spain|Sweden|United Kingdom 1
Germany|South Africa 1
Germany|United States|Austria|Finland|Italy|Netherlands|Spain|Sweden|United Kingdom 1
Greece 1
Hong Kong 1
Indonesia 1
Italy 1
Lebanon 1
Netherlands 1
Pakistan 1
Saudi Arabia 1
South Africa 1
Spain 1
United States|Australia 1
United States|Australia|Austria|Belgium|Denmark|France|Germany|Italy|Netherlands|Norway|Spain|Sweden|United Kingdom 1
United States|Australia|Bulgaria|Czechia|France|Hungary|Italy|Poland|South Africa|Spain|United Kingdom 1
United States|Austria|Finland|France|Germany|Italy 1
United States|Austria|Germany|Spain 1
United States|Belgium|France 1
United States|Bulgaria|Canada|Czechia|France|Hungary|Italy|Poland|South Africa|Spain 1
United States|Bulgaria|Canada|Finland|France|Russian Federation|Slovenia|Ukraine|United Kingdom 1
United States|Canada|Spain|United Kingdom 1
United States|Chile|France|Spain|United Kingdom 1
United States|Croatia|Germany|Russian Federation|Serbia|Spain|Ukraine 1

Sites per Study

Site_count Study_Count
1 149
2 7
3 4
4 1
5 5
6 3
7 4
8 3
9 2
10 1
11 1
12 3
15 4
16 1
17 1
18 2
19 1
21 1
24 3
25 1
26 1
28 1
30 2
34 2
37 1
38 1
39 1
42 3
44 2
45 1
46 1
49 2
50 2
52 1
54 1
62 1
65 1
70 2
71 1
80 1
83 1
85 1
92 1
110 1
125 1
228 1

Phase

Phase Study_Count
Phase 3 64
N/A 53
Phase 4 50
Phase 2 42
Phase 2/Phase 3 8
Phase 1 6
Early Phase 1 4
Phase 1/Phase 2 4

Number of Arms

Number_of_Arms Count_of_Studies
1 31
2 109
3 40
4 9
5 3
6 4
NA 35

Enrollment Metrics by Phase

Measure Early.Phase.1 N.A Phase.1 Phase.1.Phase.2 Phase.2 Phase.2.Phase.3 Phase.3 Phase.4
Min. 12.00 1.0000 9.0 6.0 14.0000 60.00 22.0000 15.00
1st Qu. 93.00 21.0000 23.0 9.0 36.5000 82.50 137.0000 47.25
Median 131.50 60.0000 34.0 20.0 73.5000 195.00 279.0000 80.50
Mean 106.25 141.8868 45.0 41.5 112.5714 224.25 278.4921 147.82
3rd Qu. 144.75 120.0000 37.5 52.5 156.7500 365.75 375.0000 183.75
Max. 150.00 1189.0000 135.0 120.0 474.0000 435.00 1000.0000 501.00

Trial Group Type

group_type Group_Count
Experimental 207
Active Comparator 115
Placebo Comparator 91
NA 35
No Intervention 14
Other 14
Sham Comparator 3

Intervention Model

intervention_model Study_Count
Parallel Assignment 170
Single Group Assignment 42
Crossover Assignment 13
Factorial Assignment 3
Sequential Assignment 2
NA 1

Primary Purpose

primary_purpose Study_Count
Treatment 176
Prevention 33
Supportive Care 7
Other 5
Basic Science 3
Health Services Research 2
NA 2
Diagnostic 1
Educational/Counseling/Training 1
Screening 1

Observational Studies

Studies by Country

Country Study_Count
United States 15
NA 7
Germany 6
China 2
France 2
Austria 1
Italy 1
Japan 1
Korea, Republic of 1
Norway 1
Panama 1
Switzerland 1
United States|Bulgaria|Canada|Croatia|France|Germany|Russian Federation|Serbia|Slovenia|Spain|Ukraine|United Kingdom 1

Sites per Study

Site_count Study_Count
1 27
2 4
4 1
18 1
80 1
84 1
127 1
159 1
251 1
317 1
785 1

Enrollment Metrics

Measure Observational
Min 23.000
1st Qu 83.500
Median 314.000
Mean 1079.359
3rd Qu 661.000
Max 14956.000

Observation Model

observational_model Study_Count
Cohort 20
NA 7
Case Control 5
Case-Control 2
Case-Only 2
Other 2
Defined Population, Natural History 1
Ecologic or Community 1

Time Perspective

time_perspective Study_Count
Prospective 32
NA 4
Retrospective 2
Cross-Sectional 1
Longitudinal, Prospective 1

Registries

Studies by Country

Country Study_Count
Thailand 1

Sites per Study

Site_count Study_Count
1 1

Enrollment Metrics

Measure Registries
Min 91
1st Qu 91
Median 91
Mean 91
3rd Qu 91
Max 91

Registry Model

observational_model Study_Count
Cohort 1

Time Perspective

time_perspective Study_Count
Prospective 1

Follow-up

target_duration Study_Count
7 Days 1

Overview of Studies

Interventional Trials

#If less then 500 trials

nct_id brief_title link overall_status source primary_completion_date
NCT03252405 Effect of Induction Method in Post Operative Agitation https://ClinicalTrials.gov/show/NCT03252405 Completed Ahi Evran University Education and Research Hospital 2017-10-30
NCT03317067 Effects of Dexmedetomidine on Delirium Duration of Non-intubated ICU Patients (4D Trial) https://ClinicalTrials.gov/show/NCT03317067 Recruiting University Hospital, Clermont-Ferrand 2021-12-21
NCT03393520 Assessment of the Efficacy, Safety, and Tolerability of AVP-786 (Deudextromethorphan Hydrobromide [d6-DM]/Quinidine Sulfate [Q]) for the Treatment of Agitation in Patients With Dementia of the Alzheimer’s Type https://ClinicalTrials.gov/show/NCT03393520 Recruiting Avanir Pharmaceuticals 2021-06-30
NCT03337529 Restless Legs Syndrome in Hemodialysis Patients https://ClinicalTrials.gov/show/NCT03337529 Completed Makassed General Hospital 2018-04-15
NCT03328676 The Effect of Cannabis on Dementia Related Agitation and Aggression https://ClinicalTrials.gov/show/NCT03328676 Recruiting TO Pharmaceuticals 2019-11-30
NCT03249779 Treatment of RLS/WED Symptoms Through Sensory Counter-stimulation https://ClinicalTrials.gov/show/NCT03249779 Completed Mayo Clinic 2018-06-30
NCT03246620 Oral Olanzapine Versus Haloperidol or Diazepam https://ClinicalTrials.gov/show/NCT03246620 Recruiting The University of Hong Kong 2020-12-31
NCT03218969 Treatment of Restless Leg Syndrome (RLS) Augmentation With Ecopipam, a D1 Specific Antagonist https://ClinicalTrials.gov/show/NCT03218969 Active, not recruiting The Methodist Hospital System 2018-09-15
NCT03216941 Randomised Trial Ketiapine Olanzapine Fast Sedation Agitated Patients Emergency Ward https://ClinicalTrials.gov/show/NCT03216941 Completed Universidad Nacional de Rosario 2016-01-01
NCT03208452 The Effect of Intraoperative Magnesium Sulfate Infusion on the Occurrence of Emergence Agitation https://ClinicalTrials.gov/show/NCT03208452 Completed Seoul National University Bundang Hospital 2018-12-19
NCT03179293 Transition to Propofol After Sevoflurane Anaesthesia to Prevent Emergence Agitation https://ClinicalTrials.gov/show/NCT03179293 Completed Assiut University 2018-06-01
NCT03171740 Premedication With Intranasal Dexmedetomidine or Midazolam for Prevention of Emergence Agitation in Children https://ClinicalTrials.gov/show/NCT03171740 Completed Brasilia University Hospital 2017-12-01
NCT03134547 A Comparison of Emergence Agitation by Sevoflurane for Intraoperative Sedation Associated With Caudal Block https://ClinicalTrials.gov/show/NCT03134547 Completed Yeungnam University College of Medicine 2016-12-31
NCT03118947 A Study of Pimavanserin for the Treatment of Agitation and Aggression in Subjects With Alzheimer’s Disease https://ClinicalTrials.gov/show/NCT03118947 Completed ACADIA Pharmaceuticals Inc. 2019-02-25
NCT03108846 Escitalopram for Agitation in Alzheimer’s Disease https://ClinicalTrials.gov/show/NCT03108846 Recruiting JHSPH Center for Clinical Trials 2021-12-31
NCT03095066 Study to Assess the Efficacy, Safety, and Tolerability of AVP-786 for the Treatment of Neurobehavioral Disinhibition Including Aggression, Agitation, and Irritability in Patients With Traumatic Brain Injury https://ClinicalTrials.gov/show/NCT03095066 Active, not recruiting Avanir Pharmaceuticals 2020-06-30
NCT03069027 Efficacy of External Nasal Nerve Block in Prevention of Postoperative Agitation Following Nasal Surgeries https://ClinicalTrials.gov/show/NCT03069027 Completed Al Jedaani Hospital 2017-04-15
NCT03062488 Emergence Agitation and Pain Scores in Pediatrics When Comparing Single-modal vs Multi-modal Analgesia for ENT Surgery https://ClinicalTrials.gov/show/NCT03062488 Completed Nemours Children’s Clinic 2018-07-11
NCT03053427 A Study of Oral Dosing of Gabapentin Enacarbil in Japanese Restless Legs Syndrome Patients https://ClinicalTrials.gov/show/NCT03053427 Completed Astellas Pharma Inc 2018-06-25
NCT02943213 Assessment of Intra-subject Variability in the Bioavailability of Chlorpromazine Hydrochloride https://ClinicalTrials.gov/show/NCT02943213 Completed Cycle Pharmaceuticals Ltd. 2016-12-31
NCT02917018 Effect of Dexmedetomidine on Stress Response and Emergence Agitation During Laparoscopic Surgery https://ClinicalTrials.gov/show/NCT02917018 Completed Assiut University 2016-12-31
NCT02909465 Reducing Ketamine-Induced Agitation, by Midazolam or Haloperidol Premedication After Adult Procedural Sedation https://ClinicalTrials.gov/show/NCT02909465 Completed Tehran University of Medical Sciences 2017-04-30
NCT02848963 Comparison of Ketamine-propofol Combinations https://ClinicalTrials.gov/show/NCT02848963 Completed Cukurova University 2017-02-28
NCT02826681 Randomized, Placebo-controlled Trial of Ferric Carboxymaltose in RLS Patients With Iron-deficiency Anemia https://ClinicalTrials.gov/show/NCT02826681 Recruiting American Regent, Inc. 2021-03-31
NCT02757495 Can Caudal Dexmedetomidine Prevents Sevoflurane Induced Emergence Agitation in Children https://ClinicalTrials.gov/show/NCT02757495 Completed Suez Canal University 2017-04-30
NCT02720705 Transbucal Dexmedetomidine for Prevention of Sevoflurane Emergence Agitation in Pre-school Children https://ClinicalTrials.gov/show/NCT02720705 Recruiting Assiut University 2018-10-31
NCT02658188 Long-term Efficacy and Safety of Gabapentin Enacarbil in Japanese Restless Legs Syndrome Patients https://ClinicalTrials.gov/show/NCT02658188 Completed Astellas Pharma Inc 2009-04-30
NCT02642315 The Effect of Horizant (Gabapentin Enacarbil) on Augmentation https://ClinicalTrials.gov/show/NCT02642315 Completed University of Missouri-Columbia 2019-05-06
NCT02613052 Agitated Saline, Albumin, or Propofol-albumin Mixture for Enhanced Contrast in TEE Examinations https://ClinicalTrials.gov/show/NCT02613052 Completed University of California, San Diego 2017-06-30
NCT02612948 Quetiapine for Delirium Prophylaxis in High-risk Critically Ill Patients https://ClinicalTrials.gov/show/NCT02612948 Completed University of Tennessee Graduate School of Medicine 2014-06-30
NCT01922258 Safety and Tolerability Study of Flexible Dosing of Brexpiprazole in the Treatment of Subjects With Agitation Associated With Dementia of the Alzheimer’s Type https://ClinicalTrials.gov/show/NCT01922258 Completed Otsuka Pharmaceutical Development & Commercialization, Inc. 2017-03-31
NCT03398759 Butorphanol Mitigate Emergence Agitation in Patients Undergoing Functional Endoscopic Sinus Surgery https://ClinicalTrials.gov/show/NCT03398759 Recruiting RenJi Hospital 2020-12-31
NCT02532608 Infra-slow Oscillations During Sleep https://ClinicalTrials.gov/show/NCT02532608 Completed Neurocenter of Southern Switzerland 2017-08-31
NCT02526277 A Study on the Use of the MMF07 Foot Massager and Heat Therapy Treatments for Restless Leg Syndrome https://ClinicalTrials.gov/show/NCT02526277 Completed Ohio State University 2018-09-25
NCT02525991 Phase IV to Evaluate the Safety of Self-administered ADASUVE® in Agitated Patients Outside the Hospital Setting https://ClinicalTrials.gov/show/NCT02525991 Recruiting Ferrer Internacional S.A. 2020-03-31
NCT02524067 Modified Environment for Agitation in Patients With TBI https://ClinicalTrials.gov/show/NCT02524067 Completed University of Aarhus 2018-05-31
NCT02499354 Pilot Study: Randomized, Placebo-controlled Comparator Trial of IV vs Oral Iron Treatment of RLS With IDA. (IVOR-IDA) https://ClinicalTrials.gov/show/NCT02499354 Recruiting Auerbach Hematology Oncology Associates P C 2020-07-31
NCT02463929 Dyphenhidramine Effect on Prevention of Sevoflurane Induced Post Anesthesia Agitation in Pediatric https://ClinicalTrials.gov/show/NCT02463929 Completed Universitas Diponegoro 2014-06-30
NCT02446132 Long Term, Extension Study of the Safety and Efficacy of AVP-786 for the Treatment of Agitation in Patients With Dementia of the Alzheimer’s Type https://ClinicalTrials.gov/show/NCT02446132 Recruiting Avanir Pharmaceuticals 2022-06-30
NCT02442778 Efficacy, Safety, and Tolerability of AVP-786 for the Treatment of Agitation in Patients With Dementia of the Alzheimer’s Type https://ClinicalTrials.gov/show/NCT02442778 Completed Avanir Pharmaceuticals 2019-08-14
NCT02442765 Efficacy, Safety and Tolerability of AVP-786 for the Treatment of Agitation in Patients With Dementia of the Alzheimer’s Type https://ClinicalTrials.gov/show/NCT02442765 Completed Avanir Pharmaceuticals 2019-01-30
NCT02428283 Scalp Nerve Block on Emergence Agitation https://ClinicalTrials.gov/show/NCT02428283 Completed Ajou University School of Medicine 2016-11-30
NCT02397057 Placebo-Controlled Study to Investigate the Efficacy & Safety of Injectafer in the Treatment of RLS https://ClinicalTrials.gov/show/NCT02397057 Active, not recruiting American Regent, Inc. 2018-04-18
NCT02386423 RESTIFFICâ„¢ Foot Wrap Reduces Moderate to Severe Restless Leg Syndrome https://ClinicalTrials.gov/show/NCT02386423 Completed Lake Erie Research Institute 2011-04-30
NCT02383004 Acupuncture for the Prevention of Emergence Delirium in Children Undergoing Myringotomy Tube Placement https://ClinicalTrials.gov/show/NCT02383004 Completed Oregon Health and Science University 2016-11-30
NCT02361476 Does Intraoperative Clonidine Reduce Post Operative Agitation in Children? https://ClinicalTrials.gov/show/NCT02361476 Completed Rigshospitalet, Denmark 2015-12-31
NCT02256358 Comparison of Effects of Intravenous Midazolam and Ketamine on Emergence Agitation https://ClinicalTrials.gov/show/NCT02256358 Completed Inje University 2014-01-31
NCT02231918 Study to Investigate Pharmacokinetics (PK) of Pramipexole in Pediatric Patients Who Are Individually Optimized to Stable Pramipexole Doses for the Treatment of Idiopathic Restless Legs Syndrome (RLS) https://ClinicalTrials.gov/show/NCT02231918 Completed Boehringer Ingelheim 2007-07-31
NCT02202720 Evaluation of Richmond Agitation Sedation Scale According to Alveolar Concentration of Sevoflurane During a Sedation With Sevoflurane in ICU Patients https://ClinicalTrials.gov/show/NCT02202720 Completed University Hospital, Clermont-Ferrand 2014-11-30
NCT02199262 Quality Improving Program on Agitation in the Surgical Intensive Care Unit https://ClinicalTrials.gov/show/NCT02199262 Completed University Hospital, Geneva 2005-01-31
NCT02181543 Use of Intraoperative Clonidine for Prevention of Postoperative Agitation in Pedriatic Anesthesia With Sevoflurane. https://ClinicalTrials.gov/show/NCT02181543 Completed Professor Fernando Figueira Integral Medicine Institute 2014-12-31
NCT02147652 Personalized Music Therapy and Agitation in Dementia https://ClinicalTrials.gov/show/NCT02147652 Enrolling by invitation University Health Network, Toronto 2020-06-30
NCT02129348 Treatment of Psychosis and Agitation in Alzheimer’s Disease https://ClinicalTrials.gov/show/NCT02129348 Completed New York State Psychiatric Institute 2020-01-31
NCT02098499 Haldol/Diphenhydramine Versus Metoclopramide/Diphenhydramine for Treatment of Acute Headache in the Emergency Department: A Randomized Controlled Trial https://ClinicalTrials.gov/show/NCT02098499 Completed United States Naval Medical Center, Portsmouth 2014-02-28
NCT02011191 Biotin Deficiency and Restless Legs Syndrome https://ClinicalTrials.gov/show/NCT02011191 Completed Saint Patrick Hospital 2007-12-31
NCT01988129 Fire Fighter Fatigue Management Program: Operation Healthy Sleep https://ClinicalTrials.gov/show/NCT01988129 Completed Brigham and Women’s Hospital 2013-09-30
NCT01981941 Post-marketing Study of Gabapentin Enacarbil to Evaluate the Effect in Restless Leg Syndrome (RLS) Patients With Moderate Renal Impairment https://ClinicalTrials.gov/show/NCT01981941 Completed Astellas Pharma Inc 2015-05-13
NCT01976871 Switching From Oral Dopamine Agonists to Rotigotine https://ClinicalTrials.gov/show/NCT01976871 Completed Massachusetts General Hospital 2015-05-31
NCT01942343 Akathisia in Post Operative Outpatients Surgery https://ClinicalTrials.gov/show/NCT01942343 Completed University Hospital, Strasbourg, France 2015-10-31
NCT01931878 Investigation of Efficacy of incobotulinumtoxinA (Xeomin) in Relieving Symptoms of Restless Leg Syndrome. https://ClinicalTrials.gov/show/NCT01931878 Completed Yale University 2015-08-31
NCT01904760 Dexmedetomidine to Prevent Agitation After Free Flap Surgery https://ClinicalTrials.gov/show/NCT01904760 Completed Peking University 2013-11-30
NCT01892579 Reducing Agitation in People With Dementia: the Customized Activity Trial https://ClinicalTrials.gov/show/NCT01892579 Completed Johns Hopkins University 2017-08-23
NCT01878656 Comparison of Emergence Agitation Between Sevoflurane and Desflurane Anesthesia After Orthognathic Surgery https://ClinicalTrials.gov/show/NCT01878656 Completed Chung-Ang University Hosptial, Chung-Ang University College of Medicine 2014-02-28
NCT01862640 A Phase 3, 12-week, Multicenter, Randomized, Double-blind, Placebo-controlled Trial to Evaluate the Efficacy, Safety, and Tolerability of 2 Fixed Doses of Brexpiprazole in the Treatment of Alzheimer’s Agitation https://ClinicalTrials.gov/show/NCT01862640 Completed Otsuka Pharmaceutical Development & Commercialization, Inc. 2017-03-15
NCT02025608 Autonomic Function and Cardiovascular Risk in Restless Legs Syndrome https://ClinicalTrials.gov/show/NCT02025608 Completed Ospedale Regionale di Lugano 2016-12-31
NCT01823770 Effect of Rotigotine Patch Treatment on Cardiovascular Markers in Idiopathic Restless Legs Syndrome https://ClinicalTrials.gov/show/NCT01823770 Completed University Hospital, Montpellier 2016-07-04
NCT01750541 Haloperidol vs. Valproate in Agitation https://ClinicalTrials.gov/show/NCT01750541 Completed Shahid Beheshti University of Medical Sciences 2012-12-31
NCT01735630 Efficacy and Safety Study of ELND005 as a Treatment for Agitation and Aggression in Alzheimer’s Disease https://ClinicalTrials.gov/show/NCT01735630 Completed OPKO Health, Inc. 2015-05-31
NCT01715506 Continuing Education in Nursing Home Dementia Care https://ClinicalTrials.gov/show/NCT01715506 Completed Bergen University College 2014-08-31
NCT01672502 Fire Fighter Fatigue Management Program: Operation Fight Fatigue https://ClinicalTrials.gov/show/NCT01672502 Completed Brigham and Women’s Hospital 2014-05-31
NCT01668667 Gabapentin Enacarbil (GSK1838262) Adult Restless Leg Syndrome Post Marketing Commitment Study https://ClinicalTrials.gov/show/NCT01668667 Completed XenoPort, Inc. 2013-11-30
NCT01617044 Probiotics in the Treatment of Iron Deficiency in Children With Restless Leg Syndrome https://ClinicalTrials.gov/show/NCT01617044 Completed Children’s Hospitals and Clinics of Minnesota 2015-11-30
NCT01584440 Efficacy, Safety and Tolerability Study of AVP-923 (Dextromethorphan/Quinidine) for Treatment of Symptoms of Agitation in Alzheimer’s Patients https://ClinicalTrials.gov/show/NCT01584440 Completed Avanir Pharmaceuticals 2014-07-31
NCT01569464 Rotigotine Effect on All-day Functioning and Quality of Life in Subjects With Moderate to Severe Restless Legs Syndrome (RLS) https://ClinicalTrials.gov/show/NCT01569464 Completed UCB Pharma 2013-04-30
NCT01562743 A Long-Term Extension Trial From Late Phase II of SPM 962 in Patients With Restless Legs Syndrome https://ClinicalTrials.gov/show/NCT01562743 Completed Otsuka Pharmaceutical Co., Ltd. 2010-10-31
NCT01537042 A Sleep Laboratory Study to Investigate the Safety and Efficacy of the Rotigotine Skin Patch in Subjects With Restless Legs Syndrome and End-Stage Renal Disease Requiring Hemodialysis https://ClinicalTrials.gov/show/NCT01537042 Completed UCB Pharma 2013-10-31
NCT01535287 Effect of Dexmedetomidine on Emergence Agitation in Children With or Without Tube Insertion Under General Anesthesia https://ClinicalTrials.gov/show/NCT01535287 Completed University of Iowa 2013-10-08
NCT01528891 Dexmedetomidine as a Rapid Bolus in Children for Emergence Agitation https://ClinicalTrials.gov/show/NCT01528891 Completed University of Pittsburgh 2014-08-31
NCT01521663 Safety and Efficacy Study of IPX159 in Restless Legs Syndrome (RLS) https://ClinicalTrials.gov/show/NCT01521663 Completed Impax Laboratories, LLC 2013-02-28
NCT01517932 Effects of Dexmedetomidine on Stress Response and Postoperative Analgesia https://ClinicalTrials.gov/show/NCT01517932 Completed Huazhong University of Science and Technology 2011-12-31
NCT01517438 Effects of Serotonin Inhibitors on Patient-controlled Analgesia Related Nausea and Vomiting https://ClinicalTrials.gov/show/NCT01517438 Completed Seoul National University Hospital 2011-12-31
NCT01506622 Comparison Between Propofol and Fentanyl for Prevention of Emergence Agitation in Children After Sevoflurane Anesthesia https://ClinicalTrials.gov/show/NCT01506622 Completed Yonsei University 2011-12-31
NCT01501123 Pre-hospital Agitation and Sedation Trial: A Randomized Controlled Trial of Haloperidol Versus Midazolam for the Sedation of the Agitated Patient https://ClinicalTrials.gov/show/NCT01501123 Completed Catholic Health East 2015-10-31
NCT01498120 Long-Term Follow-Up Study for Safety, Efficacy and Tolerability of Rotigotine in Adolescents With Restless Legs Syndrome https://ClinicalTrials.gov/show/NCT01498120 Completed UCB Pharma 2015-12-31
NCT01495793 Dose Escalating Study of Rotigotine in Pediatric Subjects With Restless Legs Syndrome https://ClinicalTrials.gov/show/NCT01495793 Completed UCB Pharma 2014-05-31
NCT01494766 Efficacy of Tyrosine in Restless Legs Syndrome https://ClinicalTrials.gov/show/NCT01494766 Completed Seton Healthcare Family 2012-05-31
NCT01485692 Four Interventions in the Management of Psychomotor Agitation, Safety and Efficacy Evaluation https://ClinicalTrials.gov/show/NCT01485692 Completed University of Sao Paulo 2011-03-31
NCT01455012 Effects of Neupro on Cardiovascular Observations in Patients With Restless Legs Syndrome https://ClinicalTrials.gov/show/NCT01455012 Completed UCB Pharma 2012-05-31
NCT01440114 The Effect of Intravenous Fentanyl Prior the End of Surgery on Emergence Agitation in Paediatric Patients After General Anesthesia https://ClinicalTrials.gov/show/NCT01440114 Completed Prince of Songkla University 2011-07-31
NCT01411124 Study to Assess the Effect of Gabapentin Enacarbil on Simulated Driving in Healthy Subjects https://ClinicalTrials.gov/show/NCT01411124 Completed XenoPort, Inc. 2011-10-31
NCT01400113 Treating Acutely Agitated Patients With Asenapine Sublingual Tablets https://ClinicalTrials.gov/show/NCT01400113 Completed St. Joseph Hospital Health Center 2012-12-31
NCT01382901 Intravenous (IV) Iron Preparation (VIT-45) in the Treatment of Restless Legs Syndrome (RLS) https://ClinicalTrials.gov/show/NCT01382901 Completed American Regent, Inc. 2007-07-31
NCT01362959 Nicotine Replacement Therapy in the Intensive Care Unit https://ClinicalTrials.gov/show/NCT01362959 Completed Gelderse Vallei Hospital 2016-08-31
NCT01332318 Simulated Driving Study in Restless Legs Syndrome https://ClinicalTrials.gov/show/NCT01332318 Completed XenoPort, Inc. 2007-11-30
NCT01332305 Dose-Response and Pharmacokinetics of Gabapentin Enacarbil (GEn [XP13512 / GSK1838262]) in Restless Legs Syndrome https://ClinicalTrials.gov/show/NCT01332305 Completed XenoPort, Inc. 2008-01-31
NCT04316052 Aerobic And Strength Training Exercises For Restless Leg Syndrome In Patients With Diabetes https://ClinicalTrials.gov/show/NCT04316052 Recruiting Riphah International University 2020-07-15
NCT04293081 Preemptive Chlorepheniramine Maleate Reducing Postoperative Agitation https://ClinicalTrials.gov/show/NCT04293081 Completed Ain Shams University 2019-05-31
NCT04276883 Dexmedetomidine in the Treatment of Agitation Associated With Bipolar Disorder https://ClinicalTrials.gov/show/NCT04276883 Recruiting BioXcel Therapeutics Inc 2020-04-30
NCT04268303 Dexmedetomidine in the Treatment of Agitation Associated With Schizophrenia https://ClinicalTrials.gov/show/NCT04268303 Recruiting BioXcel Therapeutics Inc 2020-05-01
NCT04251910 Sub-Lingual Dexmedetomidine in Agitation Associated With Dementia https://ClinicalTrials.gov/show/NCT04251910 Recruiting BioXcel Therapeutics Inc 2020-04-30
NCT04142840 Dexmedetomidine and Propofol in the Treatment of Emergence Agitation https://ClinicalTrials.gov/show/NCT04142840 Recruiting RenJi Hospital 2021-08-30
NCT04112979 Auditory Intraoperative Stimulation Effects on Pain and Agitation at Awakening (AUDIOPAW) https://ClinicalTrials.gov/show/NCT04112979 Completed IRCCS Burlo Garofolo 2019-08-23
NCT04094779 Effect of “Breath of Fresh Air” Flash Activity on Dementia Agitation : Pilot Study https://ClinicalTrials.gov/show/NCT04094779 Recruiting University Hospital, Toulouse 2020-10-20
NCT04075435 Cannabidiol Solution for the Treatment of Behavioral Symptoms in Older Adults With Alzheimer’s Dementia https://ClinicalTrials.gov/show/NCT04075435 Recruiting Mclean Hospital 2021-11-01
NCT04061681 Efficacy of BIPAMS for Restless Legs Syndrome in Adults With Multiple Sclerosis: A Pilot Study https://ClinicalTrials.gov/show/NCT04061681 Active, not recruiting University of Alabama at Birmingham 2020-07-31
NCT04058899 Dexmedetomidine Versus Nalbuphine in Prevention of Emergence Agitation Following Adenotonsillectomy in Pediatrics https://ClinicalTrials.gov/show/NCT04058899 Active, not recruiting Ain Shams University 2019-09-30
NCT04018157 Single Bolus Dose of Ketodex Versus Ketofol For Prevention Of Emergence Agitation In Adults Undergoing Nasal Surgeries https://ClinicalTrials.gov/show/NCT04018157 Completed Zagazig University 2019-11-20
NCT04010305 Sub-Lingual Dexmedetomidine in Agitation Associated With Schizophrenia https://ClinicalTrials.gov/show/NCT04010305 Completed BioXcel Therapeutics Inc 2019-07-31
NCT03992196 A Follow-up Study of Rotigotine Patch in Adolescent Subjects With Restless Legs Syndrome https://ClinicalTrials.gov/show/NCT03992196 Enrolling by invitation UCB Pharma 2024-11-30
NCT03862391 Does Low Flow Anesthesia Reduce Postanaesthetic Emergence Agitation? https://ClinicalTrials.gov/show/NCT03862391 Completed Sakarya University 2019-11-01
NCT03846284 Caudal Versus Intravenous Magnesium Sulfate on Emergence Agitation After Sevoflurane In Children. https://ClinicalTrials.gov/show/NCT03846284 Active, not recruiting Mansoura University 2018-11-15
NCT03817554 Pramipexole for Restless Leg Syndrome in Peritoneal Dialysis Patients https://ClinicalTrials.gov/show/NCT03817554 Recruiting Peking University First Hospital 2022-02-01
NCT03807011 Emergence Agitation in Pediatric Strabismus Surgery https://ClinicalTrials.gov/show/NCT03807011 Completed Yeungnam University College of Medicine 2018-10-05
NCT03806530 DIalysis Symptom COntrol-Restless Legs Syndrome Trial https://ClinicalTrials.gov/show/NCT03806530 Recruiting Population Health Research Institute 2020-08-31
NCT03728933 A Study of Rotigotine Patch in Adolescent Subjects With Restless Legs Syndrome of Unknown Cause https://ClinicalTrials.gov/show/NCT03728933 Recruiting UCB Pharma 2023-10-31
NCT03724942 Brexpiprazole for the Long-term Treatment of Patients With Agitation Associated With Dementia of the Alzheimer’s Type https://ClinicalTrials.gov/show/NCT03724942 Recruiting Otsuka Pharmaceutical Co., Ltd. 2021-05-31
NCT03710642 Prazosin for Agitation in Alzheimer’s Disease https://ClinicalTrials.gov/show/NCT03710642 Active, not recruiting Alzheimer’s Disease Cooperative Study (ADCS) 2021-12-31
NCT03681574 Gabapentin as Preanesthetic Medication to Fast Procedures in Pediatric´s Oncology https://ClinicalTrials.gov/show/NCT03681574 Completed Hospital Infantil Albert Sabin 2018-07-01
NCT03643991 Decreasing Agitation in Patients With Dementia Through the Use of Weighted Blankets https://ClinicalTrials.gov/show/NCT03643991 Recruiting Mayo Clinic 2021-03-30
NCT03624322 Safety and Tolerability of INP105 (Olanzapine by I231 POD® Device) Nasal Spray in Healthy Volunteers - SNAP 101 https://ClinicalTrials.gov/show/NCT03624322 Completed Impel NeuroPharma Inc. 2018-10-03
NCT03620981 Brexpiprazole for the Treatment of Patients With Agitation Associated With Dementia of the Alzheimer’s Type https://ClinicalTrials.gov/show/NCT03620981 Recruiting Otsuka Pharmaceutical Co., Ltd. 2021-11-30
NCT03594123 A 12-week Extension Trial to Evaluate the Safety and Tolerability of Brexpiprazole in the Treatment of Subjects With Agitation Associated With Dementia of the Alzheimer’s Type https://ClinicalTrials.gov/show/NCT03594123 Recruiting Otsuka Pharmaceutical Development & Commercialization, Inc. 2021-07-31
NCT03548584 A Trial to Evaluate the Safety, Efficacy, and Tolerability of Brexpiprazole in Treating Agitation Associated With Dementia of the Alzheimer’s Type https://ClinicalTrials.gov/show/NCT03548584 Recruiting Otsuka Pharmaceutical Development & Commercialization, Inc. 2020-11-30
NCT03548194 A Study of BNC210 in Elderly Patients With Agitation https://ClinicalTrials.gov/show/NCT03548194 Completed Bionomics Limited 2019-04-23
NCT03539081 Spinal Cord Stimulation for Restless Legs Syndrome https://ClinicalTrials.gov/show/NCT03539081 Completed University of Iowa 2020-04-23
NCT03453814 Music Intervention for Agitation Reduction in the Pediatric Intensive Care Unit https://ClinicalTrials.gov/show/NCT03453814 Completed State University of New York at Buffalo 2019-08-01
NCT01245777 Restless Legs Syndrome With Iron Deficiency or Anaemia in the 3rd Trimester of Pregnancy https://ClinicalTrials.gov/show/NCT01245777 Completed University of Zurich 2012-12-31
NCT01235143 Emergence Agitation Between Sevoflurane and Desflurane in Pediatric https://ClinicalTrials.gov/show/NCT01235143 Completed Prince of Songkla University 2012-08-31
NCT01193816 Loxapine in the Management of Restlessness During Mechanical Ventilation Weaning https://ClinicalTrials.gov/show/NCT01193816 Completed Assistance Publique - Hôpitaux de Paris 2014-05-31
NCT01183351 Multidisciplinary Intervention for Challenging Behaviour (Agitation) in Patients With Dementia https://ClinicalTrials.gov/show/NCT01183351 Completed Sykehuset Innlandet HF 2011-08-31
NCT02022488 Sevoflurane Induced Emergence Agitation https://ClinicalTrials.gov/show/NCT02022488 Completed Yeditepe University Hospital 2012-08-31
NCT01125033 Study of Vitamin C, Vitamin E and Their Combination to Treat Restless Legs Syndrome in Hemodialysis Patients https://ClinicalTrials.gov/show/NCT01125033 Completed Shiraz University of Medical Sciences 2009-01-31
NCT01119638 Escitalopram Treatment for BPSD in Alzheimer’s Disease in Comparison to Risperidone https://ClinicalTrials.gov/show/NCT01119638 Completed Abarbanel Mental Health Center 2010-04-30
NCT01084551 Study of SPM 962 in Patients With Restless Legs Syndrome (RLS) https://ClinicalTrials.gov/show/NCT01084551 Completed Otsuka Pharmaceutical Co., Ltd. 2011-09-30
NCT01069536 Efficacy and Akathisia Incidence of Slow Infusion Metoclopramide https://ClinicalTrials.gov/show/NCT01069536 Completed Pamukkale University 2007-03-31
NCT01051271 Prophylaxis Against Metoclopramide-Induced Akathisia https://ClinicalTrials.gov/show/NCT01051271 Completed Pamukkale University 2009-07-31
NCT01050478 IMPACT: A Study to Explore the Efficacy and Safety of Paliperidone ER in Patients With Acute Agitation https://ClinicalTrials.gov/show/NCT01050478 Completed Janssen Cilag N.V./S.A. 2011-12-31
NCT01021696 Pain in Patients With Dementia and Behavioural Disturbances https://ClinicalTrials.gov/show/NCT01021696 Completed University of Bergen 2010-07-31
NCT00991276 Polysomnography Study Of Pregabalin And Pramipexole Versus Placebo In Patients With Restless Legs Syndrome And Associated Sleep Disturbance https://ClinicalTrials.gov/show/NCT00991276 Completed Pfizer 2011-06-30
NCT00990769 The Effect of Depth of Anesthesia as Measured by Bispectral Index (BIS) on Emergence Agitation in Children https://ClinicalTrials.gov/show/NCT00990769 Completed Duke University 2010-09-30
NCT00949806 Restless Legs Syndrome Treatment With Botulinum Toxin https://ClinicalTrials.gov/show/NCT00949806 Completed University Hospital, Bordeaux 2011-05-31
NCT00942253 Exercise Training in Dialysis Patients With Restless Legs Syndrome (RLS) https://ClinicalTrials.gov/show/NCT00942253 Completed University of Thessaly 2010-04-30
NCT00932685 Does Distraction With a Hand Held Video Game Reduce Preoperative and Emergence Anxiety in Children? https://ClinicalTrials.gov/show/NCT00932685 Completed Rutgers, The State University of New Jersey 2007-06-30
NCT00898807 Citalopram for Agitation in Alzheimer’s Disease https://ClinicalTrials.gov/show/NCT00898807 Completed JHSPH Center for Clinical Trials 2013-09-30
NCT00895232 Iron Sucrose In The Treatment of Restless Legs Syndrome: Safety of Three Dose Regimens as Evaluated by Clinical Assessments https://ClinicalTrials.gov/show/NCT00895232 Completed American Regent, Inc. 2005-08-31
NCT00872248 Neuraxial Anesthesia and Restless Leg Syndromes in Cesarean https://ClinicalTrials.gov/show/NCT00872248 Completed Nanjing Medical University 2011-05-31
NCT00866645 A Study To Evaluate The Efficacy And Safety Of Intramuscular Levosulpiride In Patients With Agitation Of Schizophrenia https://ClinicalTrials.gov/show/NCT00866645 Completed Shanghai Mental Health Center 2010-07-31
NCT00859872 Efficacy and Safety of Risperidone Oral Solution Combination Clonazepam Versus Haloperidol Intramuscular (IM) Injection for Treatment of Acute Psychotic Agitation in Schizophrenia https://ClinicalTrials.gov/show/NCT00859872 Completed Central South University 2009-03-31
NCT00857727 Use of Dexmedetomidine to Reduce Emergence Delirium Incident in Children https://ClinicalTrials.gov/show/NCT00857727 Completed St. Luke’s-Roosevelt Hospital Center 2011-11-30
NCT00843518 Treatment for Aggression and Agitation in Patients With Alzheimer’s Disease https://ClinicalTrials.gov/show/NCT00843518 Completed Eli Lilly and Company 2011-06-30
NCT03345953 Clinical Trial Assessing the Efficacy and Safety of BP1.4979 in Restless Legs Syndrome https://ClinicalTrials.gov/show/NCT03345953 Recruiting Bioprojet 2020-03-01
NCT01848158 Acupuncture to Improve Comfort of Children on a Ventilator in the Intensive Care Unit https://ClinicalTrials.gov/show/NCT01848158 Completed Seattle Children’s Hospital 2016-06-30
NCT00806026 Long Term Study Of Pregabalin In Idiopathic Restless Legs Syndrome Patients https://ClinicalTrials.gov/show/NCT00806026 Completed Pfizer 2011-05-31
NCT04347668 Can Virtual Reality Reduce Depression and Agitation in Older Adults With Moderate to Severe Dementia? https://ClinicalTrials.gov/show/NCT04347668 Recruiting Western University, Canada 2020-05-01
NCT03528954 Propofol to Reduce the Incidence of Postanesthetic Emergence Agitation in Pediatric Patients Under General Anesthesia https://ClinicalTrials.gov/show/NCT03528954 Completed Indonesia University 2018-08-31
NCT03226522 Addressing Dementia Via Agitation-Centered Evaluation https://ClinicalTrials.gov/show/NCT03226522 Recruiting Axsome Therapeutics, Inc. 2020-06-30
NCT03213782 Effect of Nature Based Sounds’ Intervention on Agitation and Anxiety of Patients Admitted in Intensive Care Units. https://ClinicalTrials.gov/show/NCT03213782 Completed Maharishi Markendeswar University (Deemed to be University) 2017-01-07
NCT02027844 Cartoon Distraction and Parental Presence on Anxiety in Pediatric Anesthesia https://ClinicalTrials.gov/show/NCT02027844 Completed Yeungnam University College of Medicine 2015-06-30
NCT04312893 The Effectiveness of Acupuncture for Delirium in Critically Ill Patients https://ClinicalTrials.gov/show/NCT04312893 Recruiting China Medical University Hospital 2022-05-30
NCT00790075 Liquid Risperidone in the Treatment of Acute Agitation in Psychiatrically Hospitalized Children https://ClinicalTrials.gov/show/NCT00790075 Completed Stony Brook University 2004-06-30
NCT00748098 Polysomnography Study of GSK1838262 Extended Release Tablets Versus Placebo in RLS and Associated Sleep Disturbance https://ClinicalTrials.gov/show/NCT00748098 Completed XenoPort, Inc. 2009-07-31
NCT00723606 A Randomized, Open-Label, Multi-Center Study To Evaluate The Efficacy And Safety Of Intramuscular Ziprasidone In Patients With Agitation https://ClinicalTrials.gov/show/NCT00723606 Completed Pfizer 2009-07-31
NCT00723580 Actigraphic Analysis of Treatment Response https://ClinicalTrials.gov/show/NCT00723580 Completed Child Psychopharmacology Institute 2010-07-31
NCT00685815 Intravenous Iron Metabolism in Restless Legs Syndrome https://ClinicalTrials.gov/show/NCT00685815 Completed American Regent, Inc. 2010-12-31
NCT00676403 Lyrica Dose Response Study With Restless Legs Syndrome (RLS) Patients https://ClinicalTrials.gov/show/NCT00676403 Completed Pfizer 2009-01-31
NCT00666965 A Placebo-Controlled Study for SPM 962 in Restless Legs Syndrome (RLS) Patients https://ClinicalTrials.gov/show/NCT00666965 Completed Otsuka Pharmaceutical Co., Ltd. 2009-08-31
NCT00654498 Pramipexole in Out-patients With Idiopathic Restless Legs Syndrome (IRLS) https://ClinicalTrials.gov/show/NCT00654498 Completed Boehringer Ingelheim 2009-06-30
NCT00628589 Staccato Loxapine in Agitated Patients With Schizophrenia https://ClinicalTrials.gov/show/NCT00628589 Completed Alexza Pharmaceuticals, Inc. 2008-05-31
NCT00627003 A Study to Evaluate the Efficacy and Safety of Cabergoline Compared With Placebo for the Treatment of RLS https://ClinicalTrials.gov/show/NCT00627003 Completed Pfizer NA
NCT00626418 The Effects of Aplindore on the Treatment of Signs and Symptoms of Restless Legs Syndrome https://ClinicalTrials.gov/show/NCT00626418 Completed Ligand Pharmaceuticals 2008-10-31
NCT00625547 A Study to Determine the Efficacy and Safety of Cabergoline for the Treatment of Patients With RLS https://ClinicalTrials.gov/show/NCT00625547 Completed Pfizer NA
NCT00621647 Seroquel- Agitation Associated With Dementia https://ClinicalTrials.gov/show/NCT00621647 Completed AstraZeneca 2003-11-30
NCT00621517 Bupropion and Restless Legs Syndrome https://ClinicalTrials.gov/show/NCT00621517 Completed East Tennessee State University 2009-07-31
NCT00535613 Propofol in Emergence Agitation https://ClinicalTrials.gov/show/NCT00535613 Completed University of Wisconsin, Madison 2010-12-31
NCT00530790 Clinical Evaluation of Ropinirole CR-RLS ( SK&F101468)Tablets in Restless Legs Syndrome https://ClinicalTrials.gov/show/NCT00530790 Completed GlaxoSmithKline 2008-02-01
NCT00530530 ASP8825 - Study in Patients With Restless Legs Syndrome https://ClinicalTrials.gov/show/NCT00530530 Completed Astellas Pharma Inc 2009-01-31
NCT00505804 A Comparison of Dexmedetomidine and Haloperidol in Patients With Intensive Care Unit (ICU)-Associated Agitation and Delirium https://ClinicalTrials.gov/show/NCT00505804 Completed Austin Health 2008-11-30
NCT00498186 Long-term Open-label Trial in Idiopathic Restless Legs Syndrome (RLS) https://ClinicalTrials.gov/show/NCT00498186 Completed UCB Pharma 2009-04-30
NCT00498108 Phase 3 Open-label Extension Trial With Rotigotine in Idiopathic Restless Legs Syndrome Subjects https://ClinicalTrials.gov/show/NCT00498108 Completed UCB Pharma 2007-09-30
NCT00479531 Sequential Compression Devices for Treatment of Restless Legs Syndrome https://ClinicalTrials.gov/show/NCT00479531 Completed Walter Reed Army Medical Center NA
NCT00479154 Botulinum Toxin to Treat Restless Legs Syndrome https://ClinicalTrials.gov/show/NCT00479154 Completed National Institutes of Health Clinical Center (CC) 2008-04-30
NCT00472199 Long-term Efficacy, Safety and Tolerability of Pramipexole in Patients With Idiopathic Moderate to Severe Restless Legs Syndrome (RLS) https://ClinicalTrials.gov/show/NCT00472199 Completed Boehringer Ingelheim 2008-07-31
NCT00419692 Restless Legs Patient Study On Absorption, Distribution, Metabolism And Excretion Of Ropinirole And The Effect Of Food https://ClinicalTrials.gov/show/NCT00419692 Completed GlaxoSmithKline 2006-12-12
NCT00417482 Antipsychotic Discontinuation in Alzheimer’s Disease https://ClinicalTrials.gov/show/NCT00417482 Completed New York State Psychiatric Institute 2011-04-30
NCT00409370 Trial of Safety Nets In Hospitalized Patients https://ClinicalTrials.gov/show/NCT00409370 Completed Griffin Hospital NA
NCT00390689 A Randomised, Comparing Fixed Doses of Pramipexole to Investigate the Efficacy and Safety in Patients With RLS. https://ClinicalTrials.gov/show/NCT00390689 Completed Boehringer Ingelheim 2008-03-31
NCT00389831 Efficacy, Safety and Tolerability of Rotigotine Nasal Spray for the Acute Treatment of RLS Symptoms https://ClinicalTrials.gov/show/NCT00389831 Completed UCB Pharma 2006-11-30
NCT00375284 A 6 Week Trial to Study the Efficacy and Safety of a Starting Dose 0.25 mg Pramipexole (Mirapex) in Patients With RLS https://ClinicalTrials.gov/show/NCT00375284 Completed Boehringer Ingelheim 2007-07-31
NCT00373542 12-week Polysomnography Study of Ropinirole Controlled Release for Restless Legs Syndrome https://ClinicalTrials.gov/show/NCT00373542 Completed GlaxoSmithKline 2007-06-30
NCT00369577 Staccato Loxapine in Agitation (Proof of Concept) https://ClinicalTrials.gov/show/NCT00369577 Completed Alexza Pharmaceuticals, Inc. 2007-01-31
NCT00367822 Transdermal Lisuride: a Trial for the Treatment of Patients With Restless Legs Syndrome (RLS) https://ClinicalTrials.gov/show/NCT00367822 Completed Axxonis Pharma AG NA
NCT00365352 XP13512 vs. Placebo in Patients With Restless Legs Syndrome. https://ClinicalTrials.gov/show/NCT00365352 Completed XenoPort, Inc. 2007-12-31
NCT00363857 A Clinical Research Study Testing Ropinirole Treatment for Restless Legs Syndrome https://ClinicalTrials.gov/show/NCT00363857 Completed GlaxoSmithKline 2004-05-31
NCT00357097 The Effects Of Ropinirole On Mood Or Mild Depression In Patients With Moderate To Severe Restless Legs Syndrome https://ClinicalTrials.gov/show/NCT00357097 Completed GlaxoSmithKline 2007-12-31
NCT00356096 Phase IV Trial With Pramipexole to Evaluate Safety and Efficacy in Patients With RLS Associated With Mood Disturbances https://ClinicalTrials.gov/show/NCT00356096 Completed Boehringer Ingelheim 2007-06-30
NCT00355641 Long-Term Safety Of Ropinirole XR In Patients With Restless Legs Syndrome https://ClinicalTrials.gov/show/NCT00355641 Completed GlaxoSmithKline 2007-10-31
NCT00351299 Randomized Controlled Trial of Dexmedetomidine for the Treatment of Intensive Care Unit (ICU) Delirium https://ClinicalTrials.gov/show/NCT00351299 Completed Brigham and Women’s Hospital 2012-10-31
NCT00349531 A Phase IV Trial With Pramipexole to Investigate the Effects on RLS Symptoms and Sleep Disturbance in Patients With RLS https://ClinicalTrials.gov/show/NCT00349531 Completed Boehringer Ingelheim 2007-05-31
NCT00344994 SWITCH:Restless Legs Patients Switched to Ropinirole From Pramipexole https://ClinicalTrials.gov/show/NCT00344994 Completed Augusta University 2007-09-30
NCT00333359 XP13512 (Gabapentin Enacarbil) Extension Study in Patients With Restless Legs Syndrome. https://ClinicalTrials.gov/show/NCT00333359 Completed XenoPort, Inc. 2008-12-31
NCT00329602 Long-term Study Of Ropinirole In Restless Legs Syndrome https://ClinicalTrials.gov/show/NCT00329602 Completed GlaxoSmithKline 2008-09-30
NCT00314860 RLS In Adults: Comparing Immediate Release Formulation With Extended Release Formulation Of Ropinirole https://ClinicalTrials.gov/show/NCT00314860 Completed GlaxoSmithKline 2006-12-31
NCT00311363 Long-Term Study of Gabapentin Enacarbil (GEn, XP13512) vs. Placebo in Patients With Restless Legs Syndrome. https://ClinicalTrials.gov/show/NCT00311363 Completed XenoPort, Inc. 2007-11-30
NCT00298623 XP13512 (GSK1838262) Versus Placebo in Patients With Restless Legs Syndrome. https://ClinicalTrials.gov/show/NCT00298623 Completed XenoPort, Inc. 2007-02-28
NCT00275457 Efficacy and Safety of Pramipexole (PPX) in Moderate to Severe Idiopathic Restless Legs Syndrome (RLS) Patients https://ClinicalTrials.gov/show/NCT00275457 Completed Boehringer Ingelheim 2004-04-30
NCT00275236 A Sleep Lab Trial to Investigate the Efficacy and Safety of Transdermal Rotigotine in Subjects With Idiopathic Restless Legs Syndrome https://ClinicalTrials.gov/show/NCT00275236 Completed UCB Pharma 2006-07-31
NCT00263068 An Extension Trial to Investigate Long-Term Treatment With Transdermal Rotigotine in Idiopathic Restless Legs Syndrome https://ClinicalTrials.gov/show/NCT00263068 Completed UCB Pharma 2007-12-31
NCT00260624 Escitalopram Treatment of Patients With Agitated Dementia https://ClinicalTrials.gov/show/NCT00260624 Completed University of Rochester 2006-12-31
NCT00256854 Converting From Ropinirole Immediate Release (IR) To Ropinirole Controlled-Release for RLS (Restless Legs Syndrome) https://ClinicalTrials.gov/show/NCT00256854 Completed GlaxoSmithKline 2006-09-21
NCT00247364 A Double Blind Crossover Trial of Levetiracetam (Keppra®) and Placebo in the Treatment of Restless Legs Syndrome (RLS) https://ClinicalTrials.gov/show/NCT00247364 Completed Sleep Health Centers NA
NCT00243217 Rotigotine Restless Legs Syndrome Dose Finding Trial https://ClinicalTrials.gov/show/NCT00243217 Completed UCB Pharma 2004-02-29
NCT00239486 Dose Finding Study of Pramipexole (Sifrol) in Patients With Idiopathic Restless Legs Syndrome (RLS) https://ClinicalTrials.gov/show/NCT00239486 Completed Boehringer Ingelheim 2004-04-30
NCT00225862 A Clinical Research Study Evaluating Ropinirole Treatment For Restless Legs Syndrome (RLS) https://ClinicalTrials.gov/show/NCT00225862 Completed GlaxoSmithKline NA
NCT00208819 A Comparison of Two Standard Therapies in the Management of Dementia With Agitation https://ClinicalTrials.gov/show/NCT00208819 Completed Emory University NA
NCT00200941 Efficacy and Safety Study of Topiramate to Treat Restless Legs Syndrome https://ClinicalTrials.gov/show/NCT00200941 Completed Neurocare NA
NCT00199446 Study of Istradefylline (KW-6002) for the Treatment of Restless Legs Syndrome https://ClinicalTrials.gov/show/NCT00199446 Completed Kyowa Kirin Pharmaceutical Development, Inc. 2006-08-31
NCT00197080 Ropinirole XR (Extended Release) In Patients With Restless Legs Syndrome https://ClinicalTrials.gov/show/NCT00197080 Completed GlaxoSmithKline NA
NCT00161473 Alzheimer’s in Long-Term Care–Treatment for Agitation https://ClinicalTrials.gov/show/NCT00161473 Completed University of Washington 2009-09-30
NCT00152997 Pramipexole (BI-Sifrol®) Orally Once Daily for 6 Weeks in Patients With Primary Restless Legs Syndrome https://ClinicalTrials.gov/show/NCT00152997 Completed Boehringer Ingelheim 2005-12-31
NCT00152958 A Study in Patients Suffering From Idiopathic Restless Legs Syndrome Who Responded to a Preceding, 6-month Treatment With Open-label Pramipexole Including Titration (0.125, 0.25, 0.5, 0.75 mg Orally q.n.) https://ClinicalTrials.gov/show/NCT00152958 Completed Boehringer Ingelheim 2005-02-28
NCT00145691 The Effect of Oxcarbazepine in the Treatment of Agitation / Aggression in Dementia (OBAD) https://ClinicalTrials.gov/show/NCT00145691 Completed Sykehuset Innlandet HF NA
NCT00144209 Assess Efficacy and Safety of the Dopamine Agonist Pramipexole Versus Levodopa / Benserazide (Madopar® DR) in Patients With Restless Legs Syndrome https://ClinicalTrials.gov/show/NCT00144209 Completed Boehringer Ingelheim 2005-02-28
NCT00140712 Ropinirole Tablets In Young Patients With Restless Legs Syndrome https://ClinicalTrials.gov/show/NCT00140712 Completed GlaxoSmithKline 2008-02-28
NCT00136045 Three Different Transdermal Doses of Rotigotine in Subjects With Idiopathic Restless Leg Syndrome https://ClinicalTrials.gov/show/NCT00136045 Completed UCB Pharma 2006-08-31
NCT00135993 Four Different Transdermal Doses of Rotigotine in Subjects With Idiopathic Restless Legs Syndrome https://ClinicalTrials.gov/show/NCT00135993 Completed UCB Pharma 2006-11-30
NCT00133198 Efficacy and Safety of Pramipexole Compared to Placebo in the Treatment of Restless Legs Syndrome (RLS) https://ClinicalTrials.gov/show/NCT00133198 Completed Boehringer Ingelheim 2005-02-28
NCT00122733 Loxapine and Weaning From Ventilator https://ClinicalTrials.gov/show/NCT00122733 Completed Assistance Publique - Hôpitaux de Paris NA
NCT00797277 Intramuscular (IM) Olanzapine Versus IM Haloperidol Plus Lorazepam for Acute Agitation in Schizophrenia https://ClinicalTrials.gov/show/NCT00797277 Completed National Taiwan University Hospital 2009-06-30
NCT00043849 Treatment of Agitation/Psychosis in Dementia/Parkinsonism (TAP/DAP) https://ClinicalTrials.gov/show/NCT00043849 Completed National Institute on Aging (NIA) 2005-06-30
NCT00009217 Treatment of Behavioral Symptoms in Alzheimer’s Disease https://ClinicalTrials.gov/show/NCT00009217 Completed New York State Psychiatric Institute 2004-12-31
NCT00009204 Serotonergic Pharmacotherapy for Agitation of Dementia https://ClinicalTrials.gov/show/NCT00009204 Completed University of Pittsburgh 2000-04-30

Observational Studiess

#If less then 500 studies

nct_id brief_title link overall_status source primary_completion_date
NCT03211897 Olanzapine, Haloperidol, Ziprasidone, Midazolam for Acute Undifferentiated Agitation https://ClinicalTrials.gov/show/NCT03211897 Completed Hennepin Healthcare Research Institute 2017-10-01
NCT03076541 Cardiovascular Variability, Heart Rate Response, and Electromyogram Power Associated With Periodic Leg Movements. https://ClinicalTrials.gov/show/NCT03076541 Completed Centre Hospitalier Universitaire de Saint Etienne 2017-03-31
NCT02651922 Treatment of Patients Suffering From Nervous Restlessness With PASCOFLAIR® https://ClinicalTrials.gov/show/NCT02651922 Completed Pascoe Pharmazeutische Praeparate GmbH 2015-06-30
NCT02617056 Objective Assessment of Behavioral Associations of Patients With Dementia https://ClinicalTrials.gov/show/NCT02617056 Recruiting VA Office of Research and Development 2021-12-29
NCT02521259 Anesthetic Depth and the Incidence of Emergence Agitation in Children Undergoing Strabismus Surgery https://ClinicalTrials.gov/show/NCT02521259 Completed Seoul National University Bundang Hospital 2016-03-31
NCT02504450 Outcomes of Antipsychotic Medication Used in the Emergency Department https://ClinicalTrials.gov/show/NCT02504450 Completed Advocate Health Care 2016-03-31
NCT02318199 Emergence Agitation in Adult Patients After Intracranial Surgery https://ClinicalTrials.gov/show/NCT02318199 Completed Capital Medical University 2015-06-30
NCT02248155 Observational Study of Sifrol® in Patients With Primary Restless Legs Syndrome (RLS) https://ClinicalTrials.gov/show/NCT02248155 Completed Boehringer Ingelheim 2006-11-30
NCT02248142 Observational Study of Sifrol® in Patients With Primary Restless Legs Syndrome (RLS) https://ClinicalTrials.gov/show/NCT02248142 Completed Boehringer Ingelheim 2007-01-31
NCT02192554 Safety Follow-up Study for Subjects With Agitation Associated With Dementia of the Alzheimer’s Type Who Previously Participated in a Double-blind Trial of Brexpiprazole or Placebo https://ClinicalTrials.gov/show/NCT02192554 Completed Otsuka Pharmaceutical Development & Commercialization, Inc. 2017-05-31
NCT01967303 Restless Legs Syndrome in Stroke Patients https://ClinicalTrials.gov/show/NCT01967303 Completed Rambam Health Care Campus 2008-12-31
NCT01856010 Study of Electroconvulsive Therapy (ECT) Treatment for Agitation and Aggression in Dementia https://ClinicalTrials.gov/show/NCT01856010 Completed Pine Rest Christian Mental Health Services 2012-10-31
NCT01675323 Glutamate, Hyperarousal and Restless Legs Syndrome https://ClinicalTrials.gov/show/NCT01675323 Completed Johns Hopkins University 2016-07-31
NCT01538147 Restless Leg Syndrome and Severe Preeclampsia https://ClinicalTrials.gov/show/NCT01538147 Completed Saint Thomas Hospital, Panama 2017-11-30
NCT01415323 Agitation in the Acute Psychiatric Department https://ClinicalTrials.gov/show/NCT01415323 Completed Norwegian University of Science and Technology 2012-03-31
NCT04053426 Agitation Follow up After Introduction of a New Patient Care Algorithm https://ClinicalTrials.gov/show/NCT04053426 Recruiting University Hospital, Grenoble 2021-03-01
NCT03880084 Delirium, Agitation/Sedation, Pain and Dyspnea in Respiratory Intensive Care Unit (NIVILIUM) https://ClinicalTrials.gov/show/NCT03880084 Recruiting University of Modena and Reggio Emilia 2020-04-01
NCT03554915 Ketamine Versus Midazolam for Prehospital Agitation https://ClinicalTrials.gov/show/NCT03554915 Completed Hennepin Healthcare Research Institute 2018-06-25
NCT03513549 Observational Study Evaluating the Safety of ADASUVE® in Agitation Associated With Schizophrenia or Bipolar I Disorder https://ClinicalTrials.gov/show/NCT03513549 Recruiting Galen Limited 2019-10-31
NCT03457571 Clinical Observational Study: IBD Patients With Restless-legs-syndrome and Iron Deficiency Syndrome https://ClinicalTrials.gov/show/NCT03457571 Completed Charite University, Berlin, Germany 2015-02-28
NCT01174459 Survey on Long-Term Use of BI-Sifrol® Tablets in Patients With Restless Legs Syndrome https://ClinicalTrials.gov/show/NCT01174459 Completed Boehringer Ingelheim 2013-08-31
NCT01125579 Effectiveness of NEURAPAS Balance in Children With Nervous Restlessness https://ClinicalTrials.gov/show/NCT01125579 Completed Pascoe Pharmazeutische Praeparate GmbH 2008-11-30
NCT01113710 Non-interventional Study (NIS) in Patients With Restless Legs Syndrome in Daily Practise https://ClinicalTrials.gov/show/NCT01113710 Completed UCB Pharma 2011-07-31
NCT01109537 Altered Brain GABA and Glutamate in Restless Legs Syndrome https://ClinicalTrials.gov/show/NCT01109537 Completed Brigham and Women’s Hospital 2014-05-31
NCT00949858 New Data Analysis Methods for Actigraphy in Sleep Medicine https://ClinicalTrials.gov/show/NCT00949858 Completed Washington University School of Medicine 2014-01-31
NCT00887289 Non-interventional Observational Study on the Influence of Pramipexole on Sensory Symptoms of Restless Legs Syndrome (RLS) https://ClinicalTrials.gov/show/NCT00887289 Completed Boehringer Ingelheim 2009-10-31
NCT00867893 Suggested Immobilization Test (SIT) Test for Early Detection of Restless Legs Syndrome (RLS) Augmentation - Proof of Concept https://ClinicalTrials.gov/show/NCT00867893 Completed Johns Hopkins University 2012-07-31
NCT01386944 Effect on RLS Symptom Severity After Switching to Neupro® in Patients Who Previously Experienced Augmentation https://ClinicalTrials.gov/show/NCT01386944 Completed UCB Pharma 2013-08-31
NCT02559739 Sleep Deficiency and Stroke Outcome https://ClinicalTrials.gov/show/NCT02559739 Active, not recruiting University Hospital Inselspital, Berne 2020-04-30
NCT01747824 Stress Biomarkers Among Patients Undergoing Treatment for Excited Delirium and Severe Pain in the Emergency Department https://ClinicalTrials.gov/show/NCT01747824 Completed Hennepin Healthcare Research Institute 2015-12-31
NCT01329536 The Occurrence of the ApoE4 Allele in Agitated In-Patients With Late-Onset Alzheimer’s Disease https://ClinicalTrials.gov/show/NCT01329536 Completed Avera McKennan Hospital & University Health Center 2011-10-31
NCT01327339 REQUIP RLS Post Marketing Surveillance https://ClinicalTrials.gov/show/NCT01327339 Completed GlaxoSmithKline 2009-11-30
NCT00721279 Sifrol (Pramipexole) Onset of Action and Impact: a 12-weeks Observational Study in Patients With Primary Restless Legs Syndrome https://ClinicalTrials.gov/show/NCT00721279 Completed Boehringer Ingelheim 2008-10-31
NCT00590499 Agitation in Post Operative Neurosurgical Patients https://ClinicalTrials.gov/show/NCT00590499 Completed Capital Medical University 2012-12-31
NCT00557258 Cross-Sectional Study: Prevalence of Restless Legs Syndrome in Patients With Unpleasant Sensations of the Legs https://ClinicalTrials.gov/show/NCT00557258 Completed Boehringer Ingelheim 2007-11-30
NCT00539461 Non-interventional Observational Study of Pramipexole in Restless Legs Syndrome: Impact on Quality of Life https://ClinicalTrials.gov/show/NCT00539461 Completed Boehringer Ingelheim 2007-11-30
NCT00074672 Relationship Between Sensory and Motor Systems in Restless Leg Syndrome https://ClinicalTrials.gov/show/NCT00074672 Completed National Institutes of Health Clinical Center (CC) NA
NCT00065286 Akathisia (Restless Legs Syndrome) in People With Schizophrenia and Mental Retardation https://ClinicalTrials.gov/show/NCT00065286 Completed Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) NA
NCT00051961 Effect of Ropinirole on Spinal Cord Reflexes and Restless Legs Syndrome https://ClinicalTrials.gov/show/NCT00051961 Completed National Institutes of Health Clinical Center (CC) NA
NCT00001770 Progestin (Progesterone-Like Hormones) Induced Dysphoria (Depressed Mood, Irritability, Anxiety) https://ClinicalTrials.gov/show/NCT00001770 Completed National Institutes of Health Clinical Center (CC) NA

Registries

#If less then 500 registries

nct_id brief_title link overall_status source primary_completion_date
NCT03358069 Does Emergence Time Relate With Emergence Agitation in Pediatric Patients? https://ClinicalTrials.gov/show/NCT03358069 Completed Prince of Songkla University 2013-12-31